Glycoprotein IIb/IIIa integrin blockade.
نویسندگان
چکیده
Copyright © 1998 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX 72514 1998;98;2629-2635 Circulation Mina Madan, Scott D. Berkowitz and James E. Tcheng Glycoprotein IIb/IIIa Integrin Blockade http://circ.ahajournals.org/cgi/content/full/98/23/2629 located on the World Wide Web at: The online version of this article, along with updated information and services, is
منابع مشابه
Platelet glycoprotein IIb/IIIa receptor blockade improves vascular nitric oxide bioavailability in patients with coronary artery disease.
BACKGROUND Platelet glycoprotein IIb/IIIa receptor blockade not only enhances epicardial flow but also improves microvascular perfusion. Inhibition of abnormal platelet-endothelial interactions may contribute to this beneficial effect. The present study was designed to determine whether glycoprotein IIb/IIIa receptor blockade influences endothelial vasomotor function and NO bioactivity in patie...
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CONTEXT In the Enhanced Suppression of the Platelet IIb/IIIa Receptor with Integrilin Therapy (ESPRIT) trial, treatment with eptifibatide, a platelet glycoprotein IIb/IIIa integrin blocker, was found to reduce the ischemic complications of nonurgent coronary stent implantation at 48 hours and 30 days. OBJECTIVE To determine whether eptifibatide treatment continues to provide durable, long-ter...
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Occupancy of integrin receptors induces conformational changes in the receptor, resulting in exposure of novel interactive sites termed ligand-induced binding sites (LIBS). We report here that Fab fragments of certain antibodies against LIBS on integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) block platelet aggregation. Thus, certain LIBS or the regions surrounding them may participat...
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The blockade of platelet integrin glycoprotein (GP) IIb/IIIa is a promising new antiplatelet strategy. The binding of ligands or of the ligand-mimetic peptide RGD causes a conformational change of GP IIb/IIIa from the nonactivated to the activated state. Because several blocking agents/inhibitors are ligand-mimetics, the current study evaluates whether these agents have the intrinsic property t...
متن کاملInduction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (alphaIIbbeta3) inhibitors.
The blockade of platelet integrin glycoprotein (GP) IIb/IIIa is a promising new antiplatelet strategy. The binding of ligands or of the ligand-mimetic peptide RGD causes a conformational change of GP IIb/IIIa from the nonactivated to the activated state. Because several blocking agents/inhibitors are ligand-mimetics, the current study evaluates whether these agents have the intrinsic property t...
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عنوان ژورنال:
- Circulation
دوره 98 23 شماره
صفحات -
تاریخ انتشار 1998